The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001540 P06213 INSR
993 999 PLGPLYASSNPEYLSASDVF TP --- Homo sapiens (Human) 1382

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0018 two hybrid in vivo Gustafson,1995 support certain InteractionDetection
experimental MI:0424 protein kinase assay in vitro Isakoff,1996 support certain InteractionDetection
experimental MI:0018 two hybrid in vivo Isakoff,1996 support certain InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Isakoff,1996 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P35568) IRS1_HUMAN PF02174 (IRS)
PTB domain (IRS-1 type)
160 262 [mitab][xml]
(Q9Y4H2) IRS2_HUMAN PF02174 (IRS)
PTB domain (IRS-1 type)
194 296 [mitab][xml]
(P29353) SHC1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
162 318 [mitab][xml]

o  Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P06213 is implicated in the following 22 Pathways: (color codes: This sequence=red, interacting sequence=orange)

o  Diseases

  • Sequence Variation VAR_015921 (Pos 997) has been implicated in Pineal Hyperplasia, Insulin-resistant Diabetes Mellitus, And Somatic (OMIM:262190).
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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