| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001540 | P06213 INSR INSR_HUMAN |
993 | 999 | PLGPLYASSNPEYLSASDVF | TP | --- | Homo sapiens (Human) | 1382 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0018 | two hybrid | in vivo | Gustafson,1995 | support | certain | InteractionDetection |
| experimental | MI:0424 | protein kinase assay | in vitro | Isakoff,1996 | support | certain | InteractionDetection |
| experimental | MI:0018 | two hybrid | in vivo | Isakoff,1996 | support | certain | InteractionDetection |
| experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Isakoff,1996 | support | certain | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P35568) IRS1_HUMAN | PF02174
(IRS)
PTB domain (IRS-1 type) |
160 | 262 | [mitab][xml] | |
| (Q9Y4H2) IRS2_HUMAN | PF02174
(IRS)
PTB domain (IRS-1 type) |
194 | 296 | [mitab][xml] | |
| (P29353) SHC1_HUMAN | PF00640
(PID)
Phosphotyrosine interaction domain (PTB/PID) |
162 | 318 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000138:
Phosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.
Pathways
- AMPK signaling pathway
- Adherens junction
- Aldosterone regulated sodium reabsorption
- Alzheimer disease
- Diabetic cardiomyopathy
- FoxO signaling pathway
- HIF 1 signaling pathway
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway multiple species
- MAPK signaling pathway
- Non alcoholic fatty liver disease
- Ovarian steroidogenesis
- PI3K Akt signaling pathway
- Phospholipase D signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP PKG signaling pathway
- mTOR signaling pathway
Diseases
- Sequence Variation VAR_015921 (Pos 997) has been implicated in Pineal Hyperplasia, Insulin-resistant Diabetes Mellitus, And Somatic (OMIM:262190).
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement