The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001555 P05067 APP
A4_HUMAN
756 763 SKMQQNGYENPTYKFFEQMQ TP 1AQC  
pdb:1AQC 1X11  
pdb:1X11 3DXC  
pdb:3DXC 3DXD  
pdb:3DXD 3DXE  
pdb:3DXE
Homo sapiens (Human) 770

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Howell,1999 support certain
experimental MI:0074 mutation analysis in vivo/in vitro Howell,1999 support certain FeatureDetection
experimental MI:0018 two hybrid in vivo Howell,1999 support certain InteractionDetection
experimental MI:0107 surface plasmon resonance in vitro Zhang,1997 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Zhang,1997 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Radzimanowski,2008 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Radzimanowski,2008 support certain InteractionDetection FeatureDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Borg,1996 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q02410) APBA1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
461 618 0.32/0.32 [mitab][xml]
(O00213) APBB1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
0.2/0.2 [mitab][xml]
(O75553) DAB1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
42 168 0.55/0.55 [mitab][xml]

o  Switches



This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P05067 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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