The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004153 P10600 TGFB3
TGFB3_HUMAN
261 267 NEDDHGRGDLGRLKKQKDHH TP 4UM9  
Homo sapiens (Human) 412

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0411 elisa in vitro Campbell,2020 support certain InteractionDetection ParticipantIdentification
experimental MI:0074 mutation analysis in vivo/in vitro Campbell,2020 support certain FeatureDetection
experimental MI:0033 deletion analysis Dong,2014 support certain FeatureDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro Dong,2014 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Dong,2014 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P06756) ITAV_HUMAN PF01839 (FG-GAP)
FG-GAP repeat
252 286 0.0058/0.0124 [mitab][xml]
(P05106) ITB3_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
133 381 [mitab][xml]
(P18564) ITB6_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
128 375 0.0058/0.0124 [mitab][xml]
(P26012) ITB8_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
142 388 [mitab][xml]

o  Pathways

KEGG: The sequence P10600 is implicated in the following 28 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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