The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004170 Q53GL0 PLEKHO1
PKHO1_HUMAN
150 168 LAHPTRDRAKIQHSRRPPTR TP 3AA1  
Homo sapiens (Human) 409

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0045 experimental interaction detection McConnell,2020 support certain InteractionDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro McConnell,2020 support certain InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro McConnell,2020 support certain InteractionDetection
experimental MI:0045 experimental interaction detection Hernandez-Valladares,2010 support certain InteractionDetection
experimental MI:0033 deletion analysis Canton,2005 support certain FeatureDetection
experimental MI:1088 phenotype-based detection assay Canton,2005 support certain InteractionDetection
experimental MI:0403 colocalization in vitro Canton,2005 support certain
experimental MI:0943 detection by mass spectrometry in vivo/in vitro Canton,2005 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Canton,2005 support certain InteractionDetection
experimental MI:0676 tandem affinity purification Canton,2005 support certain InteractionDetection
experimental MI:1088 phenotype-based detection assay Canton,2006 support certain InteractionDetection
experimental MI:0081 peptide array Canton,2006 support certain InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro Canton,2006 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Canton,2006 support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Canton,2006 support certain
experimental MI:0074 mutation analysis in vivo/in vitro Canton,2006 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Canton,2006 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Takeda,2010 support certain InteractionDetection
experimental MI:0045 experimental interaction detection Takeda,2010 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Takeda,2010 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Takeda,2010 support certain InteractionDetection FeatureDetection
experimental MI:0405 competition binding in vitro Bruck,2006 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P14315) CAPZB_CHICK PF01115 (F_actin_cap_B)
F-actin capping protein, beta subunit
6 240 0.095/0.095 [mitab][xml]
(P47756) CAPZB_HUMAN PF01115 (F_actin_cap_B)
F-actin capping protein, beta subunit
6 240 [mitab][xml]
(P13127) CAZA1_CHICK PF01267 (F-actin_cap_A)
F-actin capping protein alpha subunit
17 282 [mitab][xml]
(P52907) CAZA1_HUMAN PF01267 (F-actin_cap_A)
F-actin capping protein alpha subunit
17 282 [mitab][xml]
(Q5RKN9) Q5RKN9_MOUSE PF01267 (F-actin_cap_A)
F-actin capping protein alpha subunit
17 282 [mitab][xml]
(Q923G3) Q923G3_MOUSE PF01115 (F_actin_cap_B)
F-actin capping protein, beta subunit
6 240 0.085/0.097 [mitab][xml]
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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