The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002947 P56524 HDAC4
HDAC4_HUMAN
349 358 PLYTSPSLPNITLGLPATGP TP 3UXG  
3V31  
Homo sapiens (Human) 1084

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0007 anti tag coimmunoprecipitation in vivo Wang,2005 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Wang,2005 support certain FeatureDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo McKinsey,2005 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro McKinsey,2005 support certain FeatureDetection
experimental MI:0416 fluorescence microscopy Wang,2005 support certain InteractionDetection
experimental MI:0018 two hybrid in vivo Wang,2005 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Wang,2005 support certain InteractionDetection
experimental MI:0663 confocal microscopy in vivo/in vitro McKinsey,2005 support certain InteractionDetection
experimental MI:0403 colocalization in vitro McKinsey,2005 support certain
experimental MI:0081 peptide array Xu,2012 support certain InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro Xu,2012 support certain InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Xu,2012 support certain FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Xu,2012 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Xu,2012 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9H9E1) ANRA2_HUMAN SM00248 (ANK)
ankyrin repeats
181 210 1.4/1.8 [mitab][xml]
(O14593) RFXK_HUMAN PF00023 (Ank)
Ankyrin repeat
123 155 86.0/132.0 [mitab][xml]
(O14593) RFXK_HUMAN SM00248 (ANK)
ankyrin repeats
123 152 86.0/132.0 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P56524 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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