ELM - instance LIG_ANK_PxLPxL_1 in sequence P56524 at position 349

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002947	P56524 HDAC4 HDAC4_HUMAN	349	358	PLYTSPSLPNITLGLPATGP	TP	3UXG 3V31	Homo sapiens (Human)	1084

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Wang,2005	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Wang,2005	support	certain	FeatureDetection
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	McKinsey,2005	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	McKinsey,2005	support	certain	FeatureDetection
experimental	MI:0416	fluorescence microscopy		Wang,2005	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Wang,2005	support	certain	InteractionDetection
experimental	MI:0096	pull down	in vivo/in vitro	Wang,2005	support	certain	InteractionDetection
experimental	MI:0663	confocal microscopy	in vivo/in vitro	McKinsey,2005	support	certain	InteractionDetection
experimental	MI:0403	colocalization	in vitro	McKinsey,2005	support	certain
experimental	MI:0081	peptide array		Xu,2012	support	certain	InteractionDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Xu,2012	support	certain	InteractionDetection
experimental	MI:0005	alanine scanning	in vivo/in vitro/in silico	Xu,2012	support	certain	FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Xu,2012	support	certain	FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Xu,2012	support	certain	InteractionDetection FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q9H9E1) ANRA2_HUMAN	SM00248 (ANK) ankyrin repeats	181	210	1.4/1.8	[mitab][xml]
(O14593) RFXK_HUMAN	PF00023 (Ank) Ankyrin repeat	123	155	86.0/132.0	[mitab][xml]
(O14593) RFXK_HUMAN	SM00248 (ANK) ankyrin repeats	123	152	86.0/132.0	[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

Pathways

KEGG: The sequence P56524 is implicated in the following 5 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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