The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002011 P35568 IRS1
IRS1_HUMAN
431 436 GFISSDEYGSSPCDFRSSFR TP --- Homo sapiens (Human) 1242

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Nakatsu,2011 support certain
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Nakatsu,2011 support certain InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Nakatsu,2011 support certain FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Nakatsu,2011 support certain FeatureDetection

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P35568 is implicated in the following 13 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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