| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002011 | P35568 IRS1 IRS1_HUMAN |
431 | 436 | GFISSDEYGSSPCDFRSSFR | TP | --- | Homo sapiens (Human) | 1242 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Nakatsu,2011 | support | certain | |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Nakatsu,2011 | support | certain | InteractionDetection |
| experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Nakatsu,2011 | support | certain | FeatureDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Nakatsu,2011 | support | certain | FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000057:
Phosphorylation of S434 in the Pin1-binding motif of Insulin receptor substrate 1 (IRS1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
Pathways
- AMPK signaling pathway
- Adipocytokine signaling pathway
- Aldosterone regulated sodium reabsorption
- Alzheimer disease
- Autophagy animal
- Diabetic cardiomyopathy
- FoxO signaling pathway
- Growth hormone synthesis, secretion and action
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway multiple species
- MicroRNAs in cancer
- Neurotrophin signaling pathway
- Non alcoholic fatty liver disease
- PI3K Akt signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP PKG signaling pathway
- mTOR signaling pathway
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement