The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004923 Q86WV6 TMEM173
STING_HUMAN
369 377 EPELLISGMEKPLPLRTDFS TP 6O8C  
Homo sapiens (Human) 379

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0119 mutation decreasing interaction in vivo/in vitro Zhang,2019 support certain InteractionDetection
experimental MI:0119 mutation decreasing interaction in vivo/in vitro Zhao,2019 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Zhao,2019 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Zhao,2019 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9UHD2) TBK1_HUMAN IPR000719 (Protein kinase domain)
Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases
9 310 [mitab][xml]
(Q9UHD2) TBK1_HUMAN IPR041309 (TANK-binding kinase 1, coiled-coil domain 1)
This is a coiled-coil domain found in TANK-binding kinase 1 (TBK1), it comprises one of two coiled-coil domains found in the scaffold dimerization region
400 655 [mitab][xml]

o  Pathways

KEGG: The sequence Q86WV6 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org