The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002058 O15169 AXIN1
21 28 SFTEDAPRPPVPGEEGELVS TP --- Homo sapiens (Human) 862

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Huang,2009 support certain
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Huang,2009 support certain InteractionDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro Guettler,2011 support likely InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Guettler,2011 support likely FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O95271) TNKS1_HUMAN PF00023 (Ank)
Ankyrin repeat
(Q9H2K2) TNKS2_HUMAN PF00023 (Ank)
Ankyrin repeat
525 557 [mitab][xml]

o  Pathways

KEGG: The sequence O15169 is implicated in the following 14 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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