The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001627 Q13464 ROCK1
ROCK1_HUMAN
394 399 FVGNQLPFVGFTYYSNRRYL TP --- Homo sapiens (Human) 1354

o  Instance evidence

Evidence classPSMI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support likely InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Pinner,2008 support likely
experimental MI:0074 mutation analysis in vivo/in vitro Pinner,2008 support likely FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O15530) PDPK1_HUMAN PF00069 (Pkinase)
Protein kinase domain
82 341 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence Q13464 is implicated in the following 18 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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