The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001626 P31749 AKT1
AKT1_HUMAN
469 474 VDSERRPHFPQFSYSASGTA U --- Homo sapiens (Human) 480

o  Instance evidence

Evidence classPSMI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0424 protein kinase assay in vivo/in vitro Biondi,2001 contradict not specified InteractionDetection
experimental MI:0405 competition binding in vitro Biondi,2001 contradict not specified InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Biondi,2001 contradict not specified FeatureDetection
experimental MI:0107 surface plasmon resonance in vitro Biondi,2001 contradict not specified InteractionDetection FeatureDetection
experimental MI:0424 protein kinase assay in vitro Scheid,2002 support not specified InteractionDetection
experimental MI:0424 protein kinase assay in vivo Scheid,2002 support not specified InteractionDetection
experimental MI:0113 western blot in vitro Scheid,2002 support not specified ParticipantIdentification FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Scheid,2002 support not specified FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O15530) PDPK1_HUMAN PF00069 (Pkinase)
Protein kinase domain
82 341 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P31749 is implicated in the following 65 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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