| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001626 | P31749 AKT1 AKT1_HUMAN |
469 | 474 | VDSERRPHFPQFSYSASGTA | U | --- | Homo sapiens (Human) | 480 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0424 | protein kinase assay | in vivo/in vitro | Biondi,2001 | contradict | not specified | InteractionDetection |
| experimental | MI:0405 | competition binding | in vitro | Biondi,2001 | contradict | not specified | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Biondi,2001 | contradict | not specified | FeatureDetection |
| experimental | MI:0107 | surface plasmon resonance | in vitro | Biondi,2001 | contradict | not specified | InteractionDetection FeatureDetection |
| experimental | MI:0424 | protein kinase assay | in vitro | Scheid,2002 | support | not specified | InteractionDetection |
| experimental | MI:0424 | protein kinase assay | in vivo | Scheid,2002 | support | not specified | InteractionDetection |
| experimental | MI:0113 | western blot | in vitro | Scheid,2002 | support | not specified | ParticipantIdentification FeatureDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Scheid,2002 | support | not specified | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (O15530) PDPK1_HUMAN | PF00069
(Pkinase)
Protein kinase domain |
82 | 341 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000002:
Phosphorylation of S473 in the PIF motif of RAC-alpha serine/threonine-protein kinase (AKT1) by Serine/threonine-protein kinase mTOR (MTOR) (as part of mTORC2 complex) induces intramolecular interaction with the PIF-binding pocket, resulting in cis-activation of RAC-alpha serine/threonine-protein kinase (AKT1). Dephosphorylation of the PIF motif by PHLPP1/2 (PHLPP1 for Akt2/3 and PHLPP2 for Akt1/3) results in reduced Akt activity, probably by disrupting the interaction with the Akt PIF pocket and thus cis-activation.
Pathways
- AGE RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Adrenergic signaling in cardiomyocytes
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy animal
- B cell receptor signaling pathway
- Breast cancer
- C type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis reactive oxygen species
- Chemical carcinogenesis receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Glucagon signaling pathway
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF 1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- JAK STAT signaling pathway
- Kaposi sarcoma associated herpesvirus infection
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway multiple species
- MAPK signaling pathway
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non alcoholic fatty liver disease
- Non small cell lung cancer
- Osteoclast differentiation
- PD L1 expression and PD 1 checkpoint pathway in cancer
- PI3K Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Progesterone mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP PKG signaling pathway
- mTOR signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement