The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002185 P05771-2 PRKCB
KPCB_HUMAN
656 661 RNIDQSEFEGFSFVNSEFLK TP --- Homo sapiens (Human) 673

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0424 protein kinase assay in vitro Edwards,1997 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Edwards,1997 support certain FeatureDetection

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
  • SWTI000003:
    ELM Switch SWTI000003

    Dephosphorylation of the PIF motif by PHLPP1/2 results in reduced stability and increased degradation of PKC. This is countered by autophosphorylation of the PIF motif, but mTORC2 might also contribute.
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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