ELM - instance DOC_AGCK_PIF_1 in sequence P05771-2 at position 656

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002185	P05771-2 PRKCB KPCB_HUMAN	656	661	RNIDQSEFEGFSFVNSEFLK	TP	---	Homo sapiens (Human)	673

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0424	protein kinase assay	in vitro	Edwards,1997	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Edwards,1997	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000003:

Dephosphorylation of the PIF motif by PHLPP1/2 results in reduced stability and increased degradation of PKC. This is countered by autophosphorylation of the PIF motif, but mTORC2 might also contribute.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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