The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001315 P05923 vpu
51 56 RLIERAEDSGNESEGEISAL TP --- Human immunodeficiency virus type 1 (BRU ISOLATE) 81

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0077 nuclear magnetic resonance in vitro Coadou,2003 support certain InteractionDetection FeatureDetection
experimental MI:0517 radiolabel in vitro Besnard-Guerin,2004 support certain
experimental MI:0663 confocal microscopy in vivo/in vitro Besnard-Guerin,2004 support certain InteractionDetection

o  Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
  • SWTI000159:
    ELM Switch SWTI000159

    Dual phosphorylation of S52 and S56 in the TrCP1-binding motif of Protein Vpu (vpu) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement