Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001305 | O00221 NFKBIE IKBE_HUMAN |
156 | 161 | EAEESQYDSGIESLRSLRSL | TP | --- | Homo sapiens (Human) | 500 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Shirane,1999 | support | likely | FeatureDetection |
experimental | MI:0517 | radiolabel | in vitro | Shirane,1999 | support | likely | |
experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Shirane,1999 | support | likely | InteractionDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000157:
Dual phosphorylation of S157 and S161 in the TrCP1-binding motif of NF-kappa-B inhibitor epsilon (NFKBIE) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Pathways
KEGG: The sequence O00221 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement