ELM - instance DEG_SCF_TRCP1_1 in sequence O00221 at position 156

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001305	O00221 NFKBIE IKBE_HUMAN	156	161	EAEESQYDSGIESLRSLRSL	TP	---	Homo sapiens (Human)	500

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Shirane,1999	support	likely	FeatureDetection
experimental	MI:0517	radiolabel	in vitro	Shirane,1999	support	likely
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Shirane,1999	support	likely	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000157:

Dual phosphorylation of S157 and S161 in the TrCP1-binding motif of NF-kappa-B inhibitor epsilon (NFKBIE) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Pathways

KEGG: The sequence O00221 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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