Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001387 | P05412 JUN JUN_HUMAN |
236 | 243 | QTVPEMPGETPPLSPIDMES | TP | --- | Homo sapiens (Human) | 331 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0573 | mutation disrupting interaction | in vivo/in vitro | Wei,2005 | support | certain | |
experimental | MI:0405 | competition binding | in vitro | Wei,2005 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000286:
Transcription factor AP-1 (JUN) is primed by an unknown kinase for phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which targets JUN to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 7 (FBXW7) that marks JUN for degradation. In v-Jun (Viral jun-transforming protein (JUN)) the residue corresponding to S243 is mutated to phenylalanine, which protects v-Jun (JUN) from degradation.
Pathways
KEGG: The sequence P05412 is implicated in the following 56 Pathways: (color codes: This sequence=red, interacting sequence=orange)- AGE RAGE signaling pathway in diabetic complications
- Amphetamine addiction
- Apoptosis
- B cell receptor signaling pathway
- Breast cancer
- C type lectin receptor signaling pathway
- Chagas disease
- Chemical carcinogenesis reactive oxygen species
- Chemical carcinogenesis receptor activation
- Choline metabolism in cancer
- Cocaine addiction
- Colorectal cancer
- Coronavirus disease COVID 19
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- GnRH signaling pathway
- Hepatitis B
- Human T cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- IL 17 signaling pathway
- Inflammatory bowel disease
- Kaposi sarcoma associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy animal
- NOD like receptor signaling pathway
- Neurotrophin signaling pathway
- Non alcoholic fatty liver disease
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD L1 expression and PD 1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pertussis
- Relaxin signaling pathway
- Renal cell carcinoma
- Rheumatoid arthritis
- Salmonella infection
- Shigellosis
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll like receptor signaling pathway
- Viral carcinogenesis
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement