ELM - instance DEG_SCF_FBW7_1 in sequence P05412 at position 236

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001387	P05412 JUN JUN_HUMAN	236	243	QTVPEMPGETPPLSPIDMES	TP	---	Homo sapiens (Human)	331

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0573	mutation disrupting interaction	in vivo/in vitro	Wei,2005	support	certain
experimental	MI:0405	competition binding	in vitro	Wei,2005	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000286:

Transcription factor AP-1 (JUN) is primed by an unknown kinase for phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which targets JUN to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 7 (FBXW7) that marks JUN for degradation. In v-Jun (Viral jun-transforming protein (JUN)) the residue corresponding to S243 is mutated to phenylalanine, which protects v-Jun (JUN) from degradation.

Pathways

KEGG: The sequence P05412 is implicated in the following 56 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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