The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
export 28 classes as:
ELM IdentifierDescriptionRegExInstancesInstances in PDB
DEG_APCC_DBOX_1 An RxxL-based motif that binds to the Cdh1 and Cdc20 components of APC/C thereby targeting the protein for destruction in a cell cycle dependent manner .R..L..[LIVM]. 11 0
DEG_APCC_KENBOX_2 Motif conserving the exact sequence KEN that binds to the APC/C subunit Cdh1 causing the protein to be targeted for 26S proteasome mediated degradation. .KEN. 16 1
DEG_APCC_TPR_1 This short C-terminal motif is present in co-activators, the Doc1/APC10 subunit and some substrates of the APC/C and mediates direct binding to TPR-containing APC/C core subunits. .[ILM]R$ 22 0
DEG_COP1_1 A destruction motif interacts with the COP1 WD 40 domain for target ubiquitination and degradation. [STDE]{1,3}.{0,2}[TSDE].{2,3}VP[STDE]G{0,1}[FLIMVYPA] 12 1
DEG_CRL4_CDT2_1 This degron overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. [NQ]{0,1}..[ILMV][ST][DEN][FY][FY].{2,3}[KR]{2,3}[^DE] 6 0
DEG_CRL4_CDT2_2 This degron, occurring in non-Vertebrates, overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. [NQ]{0,1}..[ILMV]T[DEN][HMFY][FMY].{2,3}[KR]{2,3}[^DE] 1 0
DEG_Kelch_actinfilin_1 A hydrophobic degron motif present in some kainate receptors necessary to interact with kelch domain of actinfilin protein for efficient ubiquitination and degradation. [AP]P[MV][IM]V 1 0
DEG_Kelch_Keap1_1 Motif that binds to the Kelch domain of KEAP1 with high affinity. This high affinity motif is required for the efficient recruitment of target proteins to the Cul3-based E3 ligase. [DNS].[DES][TNS]GE 13 4
DEG_Kelch_Keap1_2 Motif that binds to the Kelch domain of KEAP1 with low affinity. This low affinity motif is important for ubiquitination and degradation of target proteins. QD.DLGV 1 1
DEG_Kelch_KLHL3_1 An Acidic degron motif present in wnk kinases necessary to interact with kelch domain of KLHL2 and KLHL3 proteins for efficient ubiquitination degradation. E.EE.E[AV]DQH 4 0
DEG_MDM2_SWIB_1 An amphipatic α-helix found in p53 family members that binds in the hydrophobic cleft of MDM2's SWIB domain. F[^P]{3}W[^P]{2,3}[VIL] 5 2
DEG_Nend_Nbox_1 N-terminal motif that initiates protein degradation by binding to the N-box of N-recognins. This N-degron variant comprises N-terminal a bulky hydrophobic residue as destabilizing residue. ^M{0,1}[FYLIW][^P] 0 0
DEG_Nend_UBRbox_1 N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Arg or Lys as destabilizing residue. ^M{0,1}[RK][^P]. 0 0
DEG_Nend_UBRbox_2 N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Asp or Glu as destabilizing residue. ^M{0,1}([ED]). 0 0
DEG_Nend_UBRbox_3 N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Asn or Gln as destabilizing residue. ^M{0,1}([NQ]). 0 0
DEG_Nend_UBRbox_4 N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Cys as destabilizing residue. ^M{0,1}(C). 8 0
DEG_ODPH_VHL_1 Oxygen dependent prolyl hydroxylation motif in the unstructured region of hypoxia-inducible factor protein and bound by the VHL ligand. [IL]A(P).{6,8}[FLIVM].[FLIVM] 8 1
DEG_SCF_COI1_1 This degron motif is present in JAZ transcriptional repressor proteins and binds to the COI1 F-box protein of the SCF E3 ubiquitin ligase in a jasmonate-dependent manner. ..[RK][RK].SL..F[FLM].[RK]R[HRK].[RK]. 9 1
DEG_SCF_FBW7_1 The TPxxS phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex. [LIVMP].{0,2}(T)P..([ST]) 6 2
DEG_SCF_FBW7_2 The TPxxE phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex. [LIVMP].{0,2}(T)P..E 2 0
DEG_SCF_SKP2-CKS1_1 Degradation motif recognised by a pre-assembled complex consisting of Skp2 (an F box protein of the SCF E3 ubiquitin ligase) and Cks1, which leads to ubiquitylation and subsequent proteosomal degradation. ..[DE].(T)P.K 3 1
DEG_SCF_TIR1_1 This degron motif is present in Aux/IAA transcriptional repressor proteins and binds to TIR1/AFB F-box proteins of the SCF E3 ubiquitin ligase in an auxin-dependent manner. .[VLIA][VLI]GWPP[VLI]...R. 24 1
DEG_SCF_TRCP1_1 The DSGxxS phospho-dependent degron binds the F box protein of the SCF-betaTrCP1 complex. The degron is found in various proteins that function in regulation of cell state. D(S)G.{2,3}([ST]) 19 1
DEG_SIAH_1 The PxAxVxP peptide binds to the substrate-binding domain (SBD) of the Siah family members .P.A.V.P[^P] 9 2
DEG_SPOP_SBC_1 The S/T rich motif known as the SPOP-binding consensus (SBC) of the MATH-BTB protein, SPOP, is present in substrates that undergo SPOP/Cul3-dependant ubiquitination. [AVP].[ST][ST][ST] 8 6
LIG_APCC_Cbox_1 Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This first variant defines the motif in APC/C co-activators from Eukaryota except Fungi and Amoebozoa. [DE]R[YFH][ILFVM][PAG].R 2 0
LIG_APCC_Cbox_2 Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This second variant defines the motif in APC/C co-activators from Fungi and Amoebozoa. DR[YFH][ILFVM][PA].. 3 0
LIG_PCNA_PIPBox_1 The PCNA binding PIP box motif is found in proteins involved in DNA replication, repair and cell cycle control. ((^.{0,3})|(Q)).[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY].. 18 4
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Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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