The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

ELM candidate motifs

ELM annotation process is a tedious and time-consuming process involving critical reading of primary and secondary literature, finding motif instances, generating multiple sequence alignments and more. In order not to loose track of possible annotations, we keep the following list of candidate motifs.
We invite researchers to send us their feedback and expert opinion on these classes and to contribute novel motif classes that will be added to the candidate page and ultimately be turned into full ELM classes. Minimum requirements are at least one literature reference as well as a short description. In addition, a draft regular expression or a 3D structure showing the relevant interaction would also be helpful.

Currently 9 candidates need annotation: (Add a new candidate)

Detailed Status:
deleted: 9
Identifier Model References Description Notes Status
LIG_KLC1 [ILMV].WD.. Konecna,2006 motif mediating binding to the tetratricopeptide repeats of KLC1 duplicate of LIG_KLC1_TPR_1 deleted
LIG_Wnt LT...W Umbhauer,2000 Motif found in Frizzled (Receptor of Wnt) and involved in the activation of the Wnt/beta-catenin signaling pathway. Mutations in the fixed positions induce the expression of the Wnt target gene siamois. see LIG_Fzd_KTXXXW deleted
LIG_APCC_KILR KILR Izawa,2012 Motif in Cdc20 that mediates binding to APC/C subunits. The main determinants are the I and L residues; mutation of the basic residues decreases but not abrogates binding to both APC/C and Mad2. This same sequence also mediates binding of Cdc20 to Mad2 (see LIG_MAD2); preventing the motif to bind APC/C by hiding by Mad2 would be one of several mechanisms involved in regulation of APC/C activity and substrate specificity by the spindle assembly checkpoint. Possible interactor is Cdc23 TPR region, see Matyskiela,2009. deleted
LIG_VHS D..LL 20502673 1ELK 10985773 The VHS domain of GGA proteins binds to an acidic di-leucine motif in the cytoplasmic domain of sorting receptors including the mannose 6-phosphate receptor. duplicate of TRG_LysEnd_GGAAcLL_1 deleted
LIG_BCL2 L..I[AG]D.[ILV] 20502673 1BXL
Bcl2 motif deleted
LIG_HIV1-GP41 H..NPF 16904109 HIV-1 gp41 core-binding motif. deleted
CLV_C14_Caspase-8-10 [^RK][EDQ].D 1221285 1236692 19694615 10964557 10508785 Caspase-8 and -10 are the initiator caspase in the extrinsic apoptotic pathway and cleaves executor caspases. Motif suggestion is based on in vitro data. Optimal described sequence is LETD. For protein substrate see MEROPS or CutDB No in vitro data for caspase-10 but cleavage motif LEXD in literature is described. deleted
LIG_CD40 EQLKKSKTL 21998326 Linear peptide in an exposed loop mediates interaction between CD40L and Mac-1 might be too specific paper not freely accessible deleted
LIG_PTB_splicing [SG][IL]LG..P Rideau,2006 Motif essential for splicing repressor activity found in cofactors of the PTB regulatory splicing repressor (Polypyrimidine tract-binding protein). deleted
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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