ELM candidate motifs
ELM annotation process is a tedious and time-consuming process involving critical reading of primary and secondary literature, finding motif instances,
generating multiple sequence alignments and more.
In order not to loose track of possible annotations, we keep the following list of candidate motifs.
We invite researchers to send us their feedback and expert opinion on these
classes and to contribute novel motif classes that will be added to the candidate page and ultimately be turned into full ELM classes.
Minimum requirements are at least one literature reference as well as a short description. In addition, a draft regular expression or a 3D structure showing the relevant interaction would also be helpful.
Currently 2 candidates need annotation: (Add a new candidate)
Detailed Status:annotatable: | 2 |
Identifier | Model | References | Description | Notes | Status | |
---|---|---|---|---|---|---|
LIG_CENPC_LxxLFL_1 | F..[LM][FLY]LE[^P][VAIL] | 35420891,29280735 | Helical LxxLFL motif in CENP-C binding to the CENP-HIKM interface as part of the inner kinetochore. A second motif in CENP-C DEFxIDE binds to CENP-LN. |
annotatable |
[Edit] |
|
LIG_MOB1_1 | [YF].([ST])[AV][AV] | 23579499 4JIZ |
Interaction in the mitotic exit network (MEN) or HIPPO pathway. Cell cycle motif modified by Cdc15 kinase and then bound by Mob1 | Should be possible to derive motif by alignment due to deep conservation in eukaryotes. But should check if yeast and metazoan motifs can be represented together. |
annotatable |
[Edit] |
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement