The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004917 P10451 SPP1
OSTP_HUMAN
159 162 PTVDTYDGRGDSVVYGLRSK TP --- Homo sapiens (Human) 314

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0411 elisa in vitro Ozawa,2016 support certain InteractionDetection ParticipantIdentification
experimental MI:0517 radiolabel in vitro Hu,1995 support certain
experimental MI:0107 surface plasmon resonance in vitro Hu,1995 support certain InteractionDetection FeatureDetection
experimental MI:1088 phenotype-based detection assay Hu,1995 support certain InteractionDetection
experimental MI:0517 radiolabel in vitro Hu,1995 support certain

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P06756) ITAV_HUMAN PF01839 (FG-GAP)
FG-GAP repeat
252 286 0.00043/0.011 [mitab][xml]
(P05556) ITB1_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
138 382 0.018/0.018 [mitab][xml]
(P05106) ITB3_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
133 381 0.00043/0.011 [mitab][xml]
(P18084) ITB5_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
133 382 0.02/0.048 [mitab][xml]
(P26012) ITB8_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
142 388 [mitab][xml]

o  Pathways

KEGG: The sequence P10451 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org