The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004796 Q8N1K5 THEMIS
THMS1_HUMAN
553 560 ESSASHPPPRPPKHPSVEET TP --- Homo sapiens (Human) 641

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0416 fluorescence microscopy Paster,2013 support certain InteractionDetection
experimental MI:0367 green fluorescent protein tag in vivo Paster,2013 support certain
experimental MI:0096 pull down in vivo/in vitro Paster,2013 support certain InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Paster,2013 support certain FeatureDetection
experimental MI:0081 peptide array Paster,2013 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P62993) GRB2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
156 215 [mitab][xml]
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org