The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004791 Q13480 GAB1
GAB1_HUMAN
341 348 DTIPDIPPPRPPKPHPAHDR TP --- Homo sapiens (Human) 694

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro Harkiolaki,2003 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Lewitzky,2001 support certain InteractionDetection
experimental MI:0017 classical fluorescence spectroscopy in vitro Lewitzky,2001 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O75791) GRAP2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
271 330 146.24/146.24 [mitab][xml]
(P62993) GRB2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
156 215 21.33/24.29 [mitab][xml]

o  Pathways

KEGG: The sequence Q13480 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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