The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004783 Q9UQC2 GAB2
GAB2_HUMAN
511 519 SEIQPPPVNRNLKPDRKAKP TP 2VWF  
Homo sapiens (Human) 676

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0114 x-ray crystallography in vitro Harkiolaki,2009 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Harkiolaki,2009 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Harkiolaki,2009 support certain FeatureDetection
experimental MI:0081 peptide array Harkiolaki,2009 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Lewitzky,2001 support certain InteractionDetection
experimental MI:0017 classical fluorescence spectroscopy in vitro Lewitzky,2001 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P62993) GRB2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
156 215 3.5/3.9 [mitab][xml]

o  Pathways

KEGG: The sequence Q9UQC2 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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