The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_SH3_PxxxRxxKP_6

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004777 Q80U87 Usp8
UBP8_MOUSE 		700 708 RPAVTPMVNRENKPPCYPKA TP 1UJ0  
Mus musculus (House mouse) 1080

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0403 colocalization in vitro Berlin,2010 support certain
experimental MI:0113 western blot in vitro Berlin,2010 support certain ParticipantIdentification FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Berlin,2010 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Berlin,2010 support certain InteractionDetection
experimental MI:0081 peptide array Berlin,2010 support certain InteractionDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro Berlin,2010 support certain InteractionDetection
experimental MI:0017 classical fluorescence spectroscopy in vitro Kaneko,2003 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Kaneko,2003 support certain InteractionDetection FeatureDetection
experimental MI:0421 identification by antibody Kato,2000 support certain ParticipantIdentification
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Kato,2000 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Kato,2000 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Kato,2000 support certain InteractionDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo Kato,2000 support certain InteractionDetection
experimental MI:0033 deletion analysis Kato,2000 support certain FeatureDetection
experimental MI:0519 glutathione s tranferase tag in vitro Kato,2000 support certain
experimental MI:0047 far western blotting in vitro Kato,2000 support certain InteractionDetection
experimental MI:0033 deletion analysis Berry,2002 support certain FeatureDetection
experimental MI:0421 identification by antibody Berry,2002 support certain ParticipantIdentification
experimental MI:0113 western blot in vitro Berry,2002 support certain ParticipantIdentification FeatureDetection
experimental MI:0096 pull down in vivo/in vitro Berry,2002 support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Berry,2002 support certain

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O75791) GRAP2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		271 330 [mitab][xml]
(O89100) GRAP2_MOUSE IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		263 322 3.1/4.3 [mitab][xml]
(P62993) GRB2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		156 215 [mitab][xml]
(Q60631) GRB2_MOUSE IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		156 215 39.8/40.0 [mitab][xml]
(Q92783) STAM1_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		210 269 [mitab][xml]
(P70297) STAM1_MOUSE IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		210 269 22.3/23.1 [mitab][xml]
(O75886) STAM2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		202 261 [mitab][xml]
(O88811) STAM2_MOUSE IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		202 261 10.5/10.9 [mitab][xml]
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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