The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_SH3_PxxxRxxKP_6

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004774 Q13094 LCP2
LCP2_HUMAN 		233 241 AKLPAPSIDRSTKPPLDRSL TP 1H3H  
1OEB  
Homo sapiens (Human) 533

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0053 fluorescence polarization spectroscopy in vitro Berlin,2010 support certain InteractionDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro Sierra,2010 support certain InteractionDetection
experimental MI:0089 protein array Seet,2007 support certain InteractionDetection
experimental MI:1088 phenotype-based detection assay Seet,2007 support certain InteractionDetection
experimental MI:0081 peptide array Seet,2007 support certain InteractionDetection
experimental MI:0107 surface plasmon resonance in vitro Seet,2007 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Seet,2007 support certain InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro Harkiolaki,2003 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Harkiolaki,2003 support certain InteractionDetection FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Liu,2003 support certain InteractionDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro Liu,2003 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Liu,2003 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Liu,2003 support certain FeatureDetection
experimental MI:0077 nuclear magnetic resonance in vitro Liu,2003 support certain InteractionDetection FeatureDetection
experimental MI:0018 two hybrid in vivo Lewitzky,2001 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Lewitzky,2001 support certain InteractionDetection
experimental MI:0017 classical fluorescence spectroscopy in vitro Lewitzky,2001 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Lewitzky,2001 support certain FeatureDetection
experimental MI:0033 deletion analysis Lewitzky,2001 support certain FeatureDetection
experimental MI:0096 pull down in vivo/in vitro Lewitzky,2001 support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Lewitzky,2001 support certain
experimental MI:0033 deletion analysis Berry,2002 support certain FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Berry,2002 support certain FeatureDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro Berry,2002 support certain InteractionDetection
experimental MI:1088 phenotype-based detection assay Berry,2002 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Berry,2002 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Berry,2002 support certain InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Berry,2002 support certain FeatureDetection
experimental MI:0421 identification by antibody Berry,2002 support certain ParticipantIdentification
experimental MI:0519 glutathione s tranferase tag in vitro Berry,2002 support certain
experimental MI:0096 pull down in vivo/in vitro Berry,2002 support certain InteractionDetection
experimental MI:0081 peptide array Berry,2002 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O75791) GRAP2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		271 330 0.118/0.118 [mitab][xml]
(O89100) GRAP2_MOUSE IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		263 322 0.22/0.26 [mitab][xml]
(P62993) GRB2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		156 215 9.7/9.7 [mitab][xml]
(Q60631) GRB2_MOUSE IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		156 215 11.9/12.5 [mitab][xml]
(Q92783) STAM1_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		210 269 8.6/8.6 [mitab][xml]
(P70297) STAM1_MOUSE IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		210 269 9.0/11.0 [mitab][xml]
(O75886) STAM2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		202 261 3.8/3.8 [mitab][xml]
(O88811) STAM2_MOUSE IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues 		202 261 3.5/3.9 [mitab][xml]

o  Pathways

KEGG: The sequence Q13094 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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