The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004697 Q92844 TANK
TANK_HUMAN
180 185 TETQCSVPIQCTDKTDKQEA TP 1KZZ  
1L0A  
5H10  
Homo sapiens (Human) 425

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0114 x-ray crystallography in vitro Kim,2017 support certain InteractionDetection FeatureDetection
experimental MI:0107 surface plasmon resonance in vitro Kim,2017 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Kim,2017 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Li,2002 support certain InteractionDetection FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Li,2002 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Li,2002 support certain FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Li,2002 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q13077) TRAF1_HUMAN IPR037306 (TNF receptor-associated factor 1, MATH domain)
TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis
267 413 14.0/14.0 [mitab][xml]
(Q13114) TRAF3_HUMAN IPR037304 (TRAF3, MATH domain)
Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated p...
378 563 23.9/23.9 [mitab][xml]
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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