The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004694 P28908 TNFRSF8
TNR8_HUMAN
576 581 LGSCSDVMLSVEEEGKEDPL TP 1D01  
pdb:1D01
Homo sapiens (Human) 595

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Boucher,1997 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Boucher,1997 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Gedrich,1996 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Ye,1999 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q13077) TRAF1_HUMAN IPR037306 (TNF receptor-associated factor 1, MATH domain)
TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis
267 413 [mitab][xml]
(Q12933) TRAF2_HUMAN IPR037305 (TNF receptor-associated factor 2, MATH domain)
TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis
334 497 [mitab][xml]

o  Pathways

KEGG: The sequence P28908 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org