The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_LEDGF_IBM_1

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004528 Q03164 MLL
MLL1_HUMAN 		129 151 FRAVFGESGGGGGSGEDEQFLGF TP 2MSR  
2MTN  
3U88  
Homo sapiens (Human) 3969

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro Huang,2012 support certain InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Huang,2012 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Huang,2012 support certain InteractionDetection FeatureDetection
experimental MI:0405 competition binding in vitro Murai,2014 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Murai,2014 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Murai,2014 support certain FeatureDetection
experimental MI:0077 nuclear magnetic resonance in vitro Murai,2014 support certain InteractionDetection FeatureDetection
experimental MI:0905 amplified luminescent proximity homogeneous assay Sharma,2018 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Sharma,2018 support certain FeatureDetection
experimental MI:0405 competition binding in vitro Cermakova,2014 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Cermakova,2014 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Cermakova,2014 support certain InteractionDetection
experimental MI:0077 nuclear magnetic resonance in vitro Cermakova,2014 support certain InteractionDetection FeatureDetection
experimental MI:0905 amplified luminescent proximity homogeneous assay Cermakova,2014 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Cermakova,2014 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Cermakova,2014 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O75475) PSIP1_HUMAN IPR021567 (Lens epithelium-derived growth factor, integrase-binding domain)
Lens epithelium-derived growth factor (LEDGF), also known as transcriptional co-activator p75, is a chromatin-associated protein that protects cells from stress-induced apoptosis 		349 449 0.47/0.47 [mitab][xml]

o  Pathways

KEGG: The sequence Q03164 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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