Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI003815 | P25054 APC APC_HUMAN |
1507 | 1513 | SCSSSLSALSLDEPFIQKDV | TP | --- | Homo sapiens (Human) | 2843 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Ferrarese,2007 | support | certain | FeatureDetection |
experimental | MI:0424 | protein kinase assay | in vivo | Ferrarese,2007 | support | certain | InteractionDetection |
experimental | MI:0039 | edman degradation | in vitro | Ferrarese,2007 | support | certain | ParticipantIdentification |
Interactions
Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
---|---|---|---|---|---|
(P48729) KC1A_HUMAN | PF00069
(Pkinase)
Protein kinase domain |
17 | 259 | [mitab][xml] | |
(P48730) KC1D_HUMAN | PF00069
(Pkinase)
Protein kinase domain |
9 | 267 | [mitab][xml] | |
(Q9HCP0) KC1G1_HUMAN | PF00069
(Pkinase)
Protein kinase domain |
44 | 303 | [mitab][xml] |
Pathways
KEGG: The sequence P25054 is implicated in the following 16 Pathways: (color codes: This sequence=red, interacting sequence=orange)- Alzheimer disease
- Basal cell carcinoma
- Breast cancer
- Colorectal cancer
- Cushing syndrome
- Endometrial cancer
- Gastric cancer
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human papillomavirus infection
- MicroRNAs in cancer
- Pathways in cancer
- Pathways of neurodegeneration multiple diseases
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
- Wnt signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement