| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI003696 | Q06124 PTPN11 PTN11_HUMAN |
584 | 587 | MREDSARVYENVGLMQQQKS | TP | --- | Homo sapiens (Human) | 597 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Vogel,1996 | support | certain | FeatureDetection |
| experimental | MI:0113 | western blot | in vitro | Vogel,1996 | support | certain | ParticipantIdentification FeatureDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Vogel,1996 | support | certain | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P62993) GRB2_HUMAN | PF00017
(SH2)
SH2 domain |
60 | 135 | [mitab][xml] |
Pathways
- Adipocytokine signaling pathway
- Axon guidance
- C type lectin receptor signaling pathway
- Chemical carcinogenesis reactive oxygen species
- Chronic myeloid leukemia
- Epithelial cell signaling in Helicobacter pylori infection
- Herpes simplex virus 1 infection
- Insulin resistance
- JAK STAT signaling pathway
- Leukocyte transendothelial migration
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- PD L1 expression and PD 1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Ras signaling pathway
- Renal cell carcinoma
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement