| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length | 
|---|---|---|---|---|---|---|---|---|
| ELMI003145 |  P30279 CCND2 CCND2_HUMAN  | 
        2 | 17 | MELLCHEVDPVRRAVRDRNL | TP | --- | Homo sapiens (Human) | 289 | 
  Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes | 
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Ewen,1993 | support | certain | |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Kato,1993 | support | likely | InteractionDetection | 
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Ewen,1993 | support | likely | FeatureDetection | 
  Interactions 
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes | 
|---|---|---|---|---|---|
| (P06400) RB_HUMAN |  PF01857
                  (RB_B) 
                  Retinoblastoma-associated protein B domain  | 
             646 | 765 | [mitab][xml] | 
  Pathways 
- Cell cycle
 - Cellular senescence
 - Epstein Barr virus infection
 - Focal adhesion
 - FoxO signaling pathway
 - Hedgehog signaling pathway
 - Hippo signaling pathway
 - Human T cell leukemia virus 1 infection
 - Human papillomavirus infection
 - JAK STAT signaling pathway
 - Measles
 - MicroRNAs in cancer
 - PI3K Akt signaling pathway
 - Pathways in cancer
 - Prolactin signaling pathway
 - Transcriptional misregulation in cancer
 - Viral carcinogenesis
 - Wnt signaling pathway
 - p53 signaling pathway
 
    
        Please cite: 
            ELM-the Eukaryotic Linear Motif resource-2024 update.
        
    (PMID:37962385)
    
    
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
