The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003124 P51531 SMARCA2
SMCA2_HUMAN
1292 1308 VERLTCEEEEEKIFGRGSRQ TP --- Homo sapiens (Human) 1590

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0905 amplified luminescent proximity homogeneous assay Putta,2022 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro support likely InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Strober,1996 support likely
experimental MI:0018 two hybrid in vivo Strober,1996 support likely InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Trouche,1997 support likely FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Trouche,1997 support likely InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P06400) RB_HUMAN PF01857 (RB_B)
Retinoblastoma-associated protein B domain
646 765 24.0/24.0 [mitab][xml]
(P28749) RBL1_HUMAN IPR002719 (Retinoblastoma-associated protein, B-box)
This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also kno...
787 943 80.0/80.0 [mitab][xml]

o  Pathways

KEGG: The sequence P51531 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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