| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI003004 | Q99683 MAP3K5 M3K5_HUMAN |
963 | 968 | AGSNEYLRSISLPVPVLVED | TP |
2BR9 |
Homo sapiens (Human) | 1374 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0114 | x-ray crystallography | in vitro | Yang,2006 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Zhang,1999 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000108:
Phosphorylation of S966 in the 14-3-3-binding motif of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. This interaction inhibits the pro-apoptotic activity of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5).
Pathways
- Alzheimer disease
- Amyotrophic lateral sclerosis
- Apoptosis
- Chemical carcinogenesis reactive oxygen species
- Fluid shear stress and atherosclerosis
- Huntington disease
- Lipid and atherosclerosis
- MAPK signaling pathway
- Neurotrophin signaling pathway
- Non alcoholic fatty liver disease
- Parkinson disease
- Pathways of neurodegeneration multiple diseases
- Platinum drug resistance
- Protein processing in endoplasmic reticulum
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- TNF signaling pathway
- Thermogenesis
- Tight junction
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement