ELM - instance LIG_14-3-3_CanoR_1 in sequence P56524 at position 629

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI003001	P56524 HDAC4 HDAC4_HUMAN	629	634	GGHRPLSRAQSSPASATFPV	TP	---	Homo sapiens (Human)	1084

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0005	alanine scanning	in vivo/in vitro/in silico	Grozinger,2000	support	certain	FeatureDetection
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Grozinger,2000	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Grozinger,2000	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000116:

Phosphorylation of S632 in the 14-3-3-binding motif of Histone deacetylase 4 (HDAC4) induces binding to the 14-3-3 protein beta/alpha (YWHAB) protein. This interaction sequesters Histone deacetylase 4 (HDAC4) in the cytoplasm, thereby inhibiting their transcription repression activity.

Pathways

KEGG: The sequence P56524 is implicated in the following 5 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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