ELM - instance DOC_MAPK_RevD_3 in sequence P49137 at position 370

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002941	P49137 MAPKAPK2 MAPK2_HUMAN	370	386	QIKIKKIEDASNPLLLKRRK	TP	2OKR 4TYH	Homo sapiens (Human)	400

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Garai,2012	support	certain
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Cumming,2015	support	certain
experimental	MI:0405	competition binding	in vitro	Cumming,2015	support	certain	InteractionDetection
experimental	MI:0114	x-ray crystallography	in vitro	Cumming,2015	support	certain	InteractionDetection FeatureDetection
experimental	MI:0051	fluorescence technology		Garai,2012	support	certain	InteractionDetection
experimental	MI:0405	competition binding	in vitro	Garai,2012	support	certain	InteractionDetection
experimental	MI:0114	x-ray crystallography	in vitro	Garai,2012	support	certain	InteractionDetection FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P28482) MK01_HUMAN	PF00069 (Pkinase) Protein kinase domain	25	313	19.5/19.5	[mitab][xml]
(Q16539) MK14_HUMAN	PF00069 (Pkinase) Protein kinase domain	24	308	0.05/0.05	[mitab][xml]

Pathways

KEGG: The sequence P49137 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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