Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI002609 | P98082 DAB2 DAB2_HUMAN |
293 | 295 | NFFPTPNPDPFRDDPFTQPD | TP | --- | Homo sapiens (Human) | 770 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0007 | anti tag coimmunoprecipitation | in vivo | Morris,2001 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Morris,2001 | support | certain | FeatureDetection |
experimental | MI:0096 | pull down | in vivo/in vitro | Morris,2001 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000573:
Alternative splicing removes the AP2alpha-binding motifs of Disabled homolog 2 (DAB2), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). The p67 splice variant of Dab1 (also known as Isoform 2) does not localise to vesicles as it fails to bind the AP-2 complex.
-
SWTI000574:
Alternative splicing removes the AP2alpha-binding motifs of Disabled homolog 2 (DAB2), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). The p67 splice variant of Dab1 (also known as Isoform 2) does not localise to vesicles as it fails to bind the AP-2 complex.
Pathways
KEGG: The sequence P98082 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement