| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002604 | P60953 CDC42 CDC42_HUMAN |
188 | 191 | AILAALEPPEPKKSRRCVLL | TP | --- | Homo sapiens (Human) | 191 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:1003 | geranylgeranylase assay | Wilson,1998 | support | certain | InteractionDetection | |
| experimental | MI:0586 | inhibitor | Wilson,1998 | support | certain |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000548:
Alternative splicing removes the prenylation motif of Cell division control protein 42 homolog (CDC42), abrogating binding to Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA). The canonical, prenylated Cdc42 isoform (Cdc42-pren or Isoform Placental) is expressed in all tissues, the variant, palmitoylated form (Cdc42-palm or Isoform Brain) is expressed only in brain.
Pathways
- AGE RAGE signaling pathway in diabetic complications
- Adherens junction
- Axon guidance
- Bacterial invasion of epithelial cells
- Chemokine signaling pathway
- Endocytosis
- Epithelial cell signaling in Helicobacter pylori infection
- Fc gamma R mediated phagocytosis
- Focal adhesion
- GnRH signaling pathway
- Human papillomavirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- Neurotrophin signaling pathway
- Non alcoholic fatty liver disease
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Salmonella infection
- Shigellosis
- T cell receptor signaling pathway
- Tight junction
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement