ELM - instance TRG_NLS_MonoExtN_4 in sequence O15527 at position 333

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002593	O15527 OGG1 OGG1_HUMAN	333	339	SRHAQEPPAKRRKGSKGPEG	TP	---	Homo sapiens (Human)	345

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0416	fluorescence microscopy		Nishioka,1999	support	likely	InteractionDetection
experimental	MI:0113	western blot	in vitro	Nishioka,1999	support	likely	ParticipantIdentification FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Nishioka,1999	support	likely	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000571:

Alternative splicing removes the nuclear localisation signal (NLS) motif of N-glycosylase/DNA lyase (OGG1), abrogating binding to Importin subunit alpha-1 (KPNA1) and import into the nucleus. OGG1-1a (also known as Isoform Alpha) has a C-terminal NLS motif that is absent in OGG1-2a (also known as Isoform Beta) . Both have a weak mitochondrial localisation signal (MLS) in the N-terminal.

Pathways

KEGG: The sequence O15527 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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