| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002590 | P10636-8 MAPT TAU_HUMAN |
213 | 219 | GSRSRTPSLPTPPTREPKKV | TP | --- | Homo sapiens (Human) | 441 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | likely | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Reynolds,2008 | support | likely | |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Reynolds,2008 | support | likely | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P39688) FYN_MOUSE | PF00018
(SH3_1)
SH3 domain |
88 | 135 | 135.0/135.0 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000198:
Phosphorylation of S527 adjacent to the SH3-binding motif of Microtubule-associated protein tau (MAPT) inhibits binding to Tyrosine-protein kinase Fyn (FYN).
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement