ELM - instance LIG_TYR_ITIM in sequence Q86YW5 at position 279

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002589	Q86YW5 TREML1 TRML1_HUMAN	279	284	VLVCSKPVTYATVIFPGGNK	TP	---	Homo sapiens (Human)	311

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Barrow,2004	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Barrow,2004	support	likely	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P41499) PTN11_RAT	PF00017 (SH2) SH2 domain				[mitab][xml]

Switches

This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

SWTI000559:

Alternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Trem-like transcript 1 protein (TREML1), abrogating binding to Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).
SWTI000641:

Alternative splicing removes the ITIM (immunoreceptor tyrosine-based inhibitory motif) of Trem-like transcript 1 protein (TREML1), abrogating binding to Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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