ELM - instance TRG_ER_diArg_1 in sequence Q05586-4 at position 893

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002450	Q05586-4 GRIN1 NMDZ1_HUMAN	893	895	STLASSFKRRRSSKDTQYHP	TP	---	Homo sapiens (Human)	922

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0416	fluorescence microscopy		Standley,2001	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Standley,2001	support	likely	FeatureDetection

Switches

This ELM instance is part of the following 3 switching mechanisms annotated at the switches.ELM resource:

SWTI000589:

Binding of the PDZ domain of Disks large homolog 4 (DLG4) suppresses the ER-retention motif of Isoform 4 of Glutamate receptor subunit zeta-1 (GRIN1) in a splice variant-specific manner, thereby promoting cell surface expression of this particular isoform. This supports the hypothesis that local regulation of receptor exit from neuronal ER plays a role in modifying discrete synaptic receptor number.
SWTI000635:

Binding of the PDZ domain of Disks large homolog 4 (DLG4) suppresses the ER-retention motif of Isoform 4 of Glutamate receptor subunit zeta-1 (GRIN1) in a splice variant-specific manner, thereby promoting cell surface expression of this particular isoform. This supports the hypothesis that local regulation of receptor exit from neuronal ER plays a role in modifying discrete synaptic receptor number.
SWTI000637:

Binding of the PDZ domain of Disks large homolog 4 (DLG4) suppresses the ER-retention motif of Isoform 4 of Glutamate receptor subunit zeta-1 (GRIN1) in a splice variant-specific manner, thereby promoting cell surface expression of this particular isoform. This supports the hypothesis that local regulation of receptor exit from neuronal ER plays a role in modifying discrete synaptic receptor number.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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