ELM - instance LIG_SH3_3 in sequence Q14118 at position 888

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002281	Q14118 DAG1 DAG1_HUMAN	888	894	KGSRPKNMTPYRSPPPYVPP	TP	---	Homo sapiens (Human)	895

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0892	solid phase assay	in vitro	Russo,2000	support	certain	InteractionDetection
experimental	MI:0107	surface plasmon resonance	in vitro	Russo,2000	support	certain	InteractionDetection FeatureDetection

Switches

This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

SWTI000341:

The WW-binding motif for Dystrophin (DMD) and the SH3-binding motif for Growth factor receptor-bound protein 2 (GRB2) on Dystroglycan (DAG1) overlap, making their interactions mutually exclusive and competitive.
SWTI000660:

The WW-binding motif for Dystrophin (DMD) and the SH3-binding motif for Growth factor receptor-bound protein 2 (GRB2) on Dystroglycan (DAG1) overlap, making their interactions mutually exclusive and competitive.

Pathways

KEGG: The sequence Q14118 is implicated in the following 5 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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