Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI002262 | O15350 TP73 P73_HUMAN |
484 | 487 | VSGSHCTPPPPYHADPSLVS | TP | --- | Homo sapiens (Human) | 636 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
experimental | MI:0521 | his tag | in vivo/in vitro/in silico | Strano,2001 | support | certain | |
experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
experimental | MI:0519 | glutathione s tranferase tag | in vitro | Strano,2001 | support | certain | |
experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
experimental | MI:0519 | glutathione s tranferase tag | in vitro | Rossi,2005 | support | certain | |
experimental | MI:0997 | ubiquitinase assay | in vitro | Rossi,2005 | support | certain | InteractionDetection |
experimental | MI:0007 | anti tag coimmunoprecipitation | in vivo | Rossi,2005 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Rossi,2005 | support | certain | FeatureDetection |
experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Strano,2001 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Strano,2001 | support | certain | FeatureDetection |
Interactions
Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
---|---|---|---|---|---|
(Q96J02) ITCH_HUMAN | PF00397
(WW)
WW domain |
[mitab][xml] | |||
(P46937) YAP1_HUMAN | PF00397
(WW)
WW domain |
[mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000678:
The transcriptional coactivator YAP1 and the ubiquitin ligase Itch competitively bind to the same WW-binding motif of p73. Binding of YAP1 prevents Itch-mediated ubiquitylation of p73, resulting in stabilisation, and increases trancriptional activity of p73.
Pathways
KEGG: The sequence O15350 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement