ELM - instance MOD_CK1_1 in sequence P46937-2 at position 381

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002260	P46937-2 YAP1 YAP1_HUMAN	381	387	YHSRDESTDSGLSMSSYSVP	TP	---	Homo sapiens (Human)	488

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Zhao,2010	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Zhao,2010	support	likely	FeatureDetection
experimental	MI:0586	inhibitor		Zhao,2010	support	certain
experimental	MI:0517	radiolabel	in vitro	Zhao,2010	support	certain
experimental	MI:0424	protein kinase assay	in vitro	Zhao,2010	support	certain	InteractionDetection
experimental	MI:0424	protein kinase assay	in vivo	Zhao,2010	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Zhao,2010	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

SWTI000691:

Phosphorylation of Yorkie homolog (YAP1) at S381 by Serine/threonine-protein kinase LATS1 (LATS1) (a key regulator of the Hippo Pathway) primes the sequence for phosphorylation by Casein kinase I isoform epsilon (CSNK1E) at S384 and S387. This targets YAP1 to the SCF ubiqutin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks is YAP1 for subsequent degradation by the proteasomal system. N.B. Serine/threonine-protein kinase LATS2 (LATS2) can replace LATS1 and Casein kinase I isoform delta (CSNK1D) can replace CSNK1E
SWTI000691:

Phosphorylation of Yorkie homolog (YAP1) at S381 by Serine/threonine-protein kinase LATS1 (LATS1) (a key regulator of the Hippo Pathway) primes the sequence for phosphorylation by Casein kinase I isoform epsilon (CSNK1E) at S384 and S387. This targets YAP1 to the SCF ubiqutin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks is YAP1 for subsequent degradation by the proteasomal system. N.B. Serine/threonine-protein kinase LATS2 (LATS2) can replace LATS1 and Casein kinase I isoform delta (CSNK1D) can replace CSNK1E

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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