ELM - instance LIG_SH2_STAT5 in sequence Q15303 at position 1056

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002194	Q15303 ERBB4 ERBB4_HUMAN	1056	1059	IGHSPPPAYTPMSGNQFVYR	TP	---	Homo sapiens (Human)	1308

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0089	protein array		Kaushansky,2008	support	certain	InteractionDetection
experimental	MI:0068	mass detection of residue modification	in vitro	Kaushansky,2008	support	certain	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Cohen,1996	support	certain	InteractionDetection
experimental	MI:0405	competition binding	in vitro	Cohen,1996	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000290:

Phosphorylation-dependent binding of Receptor tyrosine-protein kinase erbB-4 (ERBB4) to the SH2 domains of Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) results in signaling activation, while binding to the WW domains of E3 ubiquitin-protein ligase Itchy homolog (ITCH) to unphopshorylated ERBB4 results in ubiquitylation, endocytosis and ultimately degradation of ERBB4.

Pathways

KEGG: The sequence Q15303 is implicated in the following 6 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement